Intracellular C. neoformans modulates macrophage NF-κB signaling 1 MODULATION OF MACROPHAGE INFLAMMATORY NF-κB SIGNALING BY INTRACELLULAR CRYPTOCOCCUS NEOFORMANS

نویسندگان

  • James B. Hayes
  • Linda M. Sircy
  • Lauren E. Heusinkveld
  • Wandi Ding
  • Rachel N. Leander
  • Erin E. McClelland
  • David E. Nelson
چکیده

Cryptococcus neoformans (Cn) is a sporeforming, intracellular pathogenic yeast found in soil and other niches worldwide (1). Inhalation of spores is thus extremely common, allowing Cn to infect ~70% of children in urban environments (2). In most cases Cn infections do not present immediate clinical symptoms; rather, Cn is able to enter a chronic latent state that may last for many years by residing within host macrophages. However, in immune compromised individuals, an acute Cn infection or re-emergence of an existing infection can result in life-threatening conditions such as pneumonia or fungal meningitis. A recent estimate suggests these and other Cn-related illnesses cause ~600,000 deaths per year (3). A key regulator of this host:pathogen interaction is the Cn polysaccharide capsule. The capsule, primarily composed of http://www.jbc.org/cgi/doi/10.1074/jbc.M116.738187 The latest version is at JBC Papers in Press. Published on May 26, 2016 as Manuscript M116.738187

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تاریخ انتشار 2016